‘Your donations can make a significant contribution towards colorectal tumor research at BC Malignancy Agency. In the last 10 years major progress has been made in medical, radiation and systemic remedies. But more is needed, as colorectal cancer is the second most common cause of cancers death in Canada still. Our research now is centered on personalizing colorectal cancer therapy by determining the cancer tumor mutations and subtypes and conducting medical trials to discover targeted treatment for each of these.’ Related StoriesMD Anderson study reveals why chemotherapy medicines not effective for many pancreatic cancer patientsCrucial transformation in single DNA base predisposes children to aggressive form of cancerNew RNA test of blood platelets can be used to detect area of cancerBC Cancer Basis Board chair John Jennings, husband of Gala Co-Chair Christine Jennings, underscored his because of guests because of their donations by performing a piano rendition of the Beatles’ tune ‘With a little help from my friends’, adding, ‘We are deeply grateful to everyone here tonight for their extraordinary generosity in helping this underfunded malignancy.Conventional medicines function by binding to a target protein directly typically, to hinder the action of the disease causing protein. Antisense medications on the other hand, are rationally made to bind to a particular messenger RNA sequence where they catch the attention of the enzyme RNase H to damage the messenger RNA through the entire cell,and thus block or stop the production of the disease causing protein in the first instance. In acromegaly, our treatment inhibits the production of the growth hormones receptor in the liver, which reduces levels of IGFI in the blood. This siRNA binds to an RNA-Induced Silencing Complex which separates both strands, taking one strand to a messenger RNA site to be cleaved to avoid the production of the prospective protein.