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Ways to improve adherence can include involving the individual’s health care ecosystem, addressing the patient’s major reason for adherence such as for example forgetfulness, and providing counseling and feedback. The adherence problem must also become tackled as a group— not only by the ongoing healthcare system, but also through patient social networks. The worthiness of caregivers should not be overlooked, Buono stated. Patient medication nonadherence is usually unlikely to be tackled by a single intervention or intervener adequately, she wrote. This challenging problem must be addressed with multilayer, multifaceted, multisystem approaches designed in response to create engagement evaluation and collaboration.