Researcher Tung-Ping Su and colleagues remember that this is in line with previous results and evidence suggesting an association between ADHD and feeling dysregulation and bipolar disorder. All rights reserved. Neither of the parties endorse or recommend any commercial products, services, or equipment.. ADHD increases major unhappiness to bipolar disorder conversion By Lucy Piper, Senior medwireNews Reporter Teenagers with major major depression have an increased threat of transformation to bipolar disorder if indeed they have comorbid attention deficit/hyperactivity disorder , suggest findings from a longitudinal follow-up study. The total results showed that 1193 people with major despression symptoms and comorbid ADHD were 1.5 times more likely to develop subsequent bipolar disorder than 56,830 people with major depression alone.No further adjustments for multiplicity have been made, because the efficacy outcome for every dose group was considered to be successful only if there were significant improvements over placebo in both coprimary efficacy end points. In general, missing values were imputed for the statistical analyses with the use of the last available post-baseline value up to enough time point of interest. We performed a sensitivity analysis that included four patients, all in the 10-mg ulipristal acetate group, who did not have any efficacy data while getting treatment, using baseline data carried forwards.33 Extra binary end points were analyzed in a similar way.34 The changes from baseline in PBAC scores and in pain assessments were analyzed in a similar way.