After weight reduction, there is a marked improvement in insulin sensitivity on oral glucose-tolerance testing, with reductions in plasma glucose and plasma insulin concentrations and an increase in the insulin-sensitivity index . Effect of PNPLA3 Genotype on Hepatic Steatosis The liver triglyceride content was also increased in subjects of the CG and GG genotypes at rs738409 in PNPLA3, in comparison with subjects of the CC genotype, with the use of both a dominant model and an additive model .11 Variants in APOC3 alone, PNPLA3 alone, and both types combined accounted, respectively, for 11.0, 6.5, and 13.1 percent of the variance in the chance of non-alcoholic fatty liver disease.As women age group, the protein production decreases and causes skin to sag and wrinkle. Worse Even, this sluggish down can occur as young as 20. A good way to prevent that is to eat regular servings of citric fruits. All citruses are high in supplement C, which, furthermore to boosting your immune system, boosts collagen production resulting in fewer wrinkles also. While citrus fruit protects your skin inside from lines and wrinkles, tomatoes perform their job on the outside by protecting your skin from harmful light.