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Abnormal connections created by central nervous system associated with persistence of chronic pain Chronic pain is an epidemic. One reason for the persistence of persistent pain may be that the patient’s central anxious system creates abnormal connections or boosts connections that must not be strengthened, clarifies Susan G. Dorsey, PhD, RN, co-director of the institution of Nursing’s Middle of Excellence in Disorders of Neuroregulatory Function. Chronic pain makes a memory space that must not be made, such as the lasting harm to peripheral nerves sometimes due to cancer drugs, she says. The discomfort can still last after tumor treatment stops, and once memories are produced, they are tough to unlearn. Discovering why the central nervous program creates improper connections is usually a simple definition of the Center’s complex, cutting-edge research carried out by Dorsey, co-director Christopher Ward, PhD, and their team of pupil and faculty investigators, who study the molecular, cellular, and genetic mechanisms underlying the persistence and development of chronic pain.