A biochemical alteration that inactivates critical tumor-suppressor genes.

The MS-qFRET process starts by treating sample DNA with sodium bisulfite, which converts all unmethylated cytosines into uracil, leaving any methylated cytosines unchanged. The treated DNA then is amplified using a altered polymerase chain reaction process that differentiates between methylated and unmethylated DNA. This procedure also introduces fluorescent biotin and markers molecules on each little bit of methylated DNA. Finally, streptavidin-coated quantum dots are put into the amplified DNA, binding to the biotin-connected DNA molecules tightly.‘Concentrating on the MIP Point frees the doctor from trying to imagine the optimal point for embryo placement,’ Dr. Gergely stated. ‘By overcoming the limitations of 2D ultrasound, 3D/4D ultrasound-guided embryo transfer targeting the Maximal Implantation Potential Point increases the pregnancy rate while considerably reducing the chance of ectopic pregnancy and complications associated with multiple births.’ Dr. Gergely, who created and retains the patent on 3D/4D ultrasound-guided embryo transfer, lectures at international teaches and conferences doctors so the procedure can become open to patients worldwide.