We also believe that enough time to full individual enrollment in this research also to potential regulatory approval of ponatinib will end up being swift. .. ARIAD commences ponatinib Phase 2 clinical trial in Ph+ ALL and chronic myeloid leukemia ARIAD Pharmaceuticals, Inc. today announced the initiation of the pivotal Phase 2 clinical trial of its investigational pan-BCR-ABL inhibitor, ponatinib , in patients with resistant or intolerant chronic myeloid leukemia and Philadelphia positive acute lymphoblastic leukemia . The Speed trial is made to provide definitive medical data for regulatory authorization of ponatinib in this placing.The incidence rates of infection and severe malaria are similar to people with been reported in other areas of high transmission19,20 . The median age at the first episode of severe malaria was 38.7 weeks . The risk of severe malaria didn’t decrease after the first infection; approximately 50 percent of children experienced at least two mild or asymptomatic attacks before their first severe episode . Severe Malarial Anemia As in other African communities,21,22 most children with severe malaria typically presented with a single condition , such as respiratory distress, convulsions, or severe anemia. Children had several condition in mere 12.3 percent of severe episodes , which is comparable to the proportions reported in prior studies.21,22 Kids with convulsions were older and had reduce parasite densities than children with severe anemia, although the differences were not significant .