The patients receiving MSAT were standing with assistance on both sides by wrapping their hands around clinicians’s shoulders while one of the clinicians inserted needles relating to founded Traditional Chinese Medicine standards. Then the patients were assisted with strolling as the needles remained inserted. As the pain subsided, the assistance was decreased until the patient could walk unassisted without great pain gradually. This process usually took 20 moments, with immediate results.Furthermore, we hypothesized that removing NRTIs entirely will be noninferior to the standard regimen ,6-8 with the advantage of reduced toxicity, regimen complexity, and cost. Methods Study Patients From 12 April, 2010, to April 29, 2011, we recruited individuals at 14 centers in five sub-Saharan African countries. Eligible individuals were HIV-infected adults or adolescents who had received first-line antiretroviral therapy consisting of two NRTIs and one NNRTI continuously for a lot more than 12 months, hadn’t received a protease inhibitor previously, had missed only 3 times of treatment during the preceding month, and had virologic, immunologic, or clinical treatment failure . Details are provided in the Methods section in the Supplementary Appendix and in the scholarly study protocol, both of which can be found with the entire text of this content at NEJM.org.