Dr. Coppo concludes, ‘It really is of interest that most of the sufferers with IgAN who enter dialysis are middle-aged, and since the disease takes decades to progress, it is likely that their disease started in childhood.’.. ACE inhibitors help preserve kidney function in IgA nephropathy For young individuals with the kidney disease IgA nephropathy , early treatment with angiotensin-converting enzyme inhibitors can reduce the long-term risk of irreversible kidney damage, suggests a study in the June Journal of the American Society of Nephrology. ‘These results in young individuals are of particular interest because they can offer a way of limiting the near future need for renal substitute therapy in individuals with IgAN,’ remarks Dr.Qualifying imaging had to be performed in a scholarly research hospital; imaging was repeated for patients who were transferred from outside hospitals. Detailed research inclusion and exclusion requirements are provided in Table S1 in the Supplementary Appendix. To recognize patients with salvageable tissue, at trial release the entry criteria regarding imaging selection required patients to have a target-mismatch penumbral profile, with a little core of tissue that was apt to be irreversibly injured and a large region of hypoperfused cells that was apt to be salvageable.